Previous studies demonstrated that when cervical carcinoma cells are cultured under hypoxia, increased activity of PI3K/mTORC2/ AKT signaling pathway can mediate suppression of HPV oncoproteins like E6 and E7 (Hoppe-Seyler et al., 2017[71]; Bossler et al., 2019[15]). Here, PIK3CD is linked to cervical carcinoma.