The type of cell, the stage of the tumor, the genetic history of the tumor, and the cell differentiation condition characterizes the oncogenic or anti-oncogenic AP-1 (Shen et al., 2005[137]) via interaction with the promoter of HPV situated in the upstream regulatory region (URR), which intensifies tumorigenesis and E6 and E7 transcription. This evidence concerns the gene JUNB and neoplasm.