INS and obesity due to melanocortin 4 receptor deficiency: T2DM, metabolic syndrome and obesity are characterized by the insulin resistance and the impairment in the insulin secretion which both are tightly associated with the impairment in the adipose tissue functions, and increased levels of reactive oxygen species (ROS) termed as oxidative stress [10], [11], [12], [13], [14], [15], [16], [17], [18].