In addition, Liu et al. provided novel evidence that the interplay between the signals of the mechanistic target of rapamycin kinase and GPX4 modulates autophagy-dependent ferroptosis in human pancreatic cancer cells, and the down-regulation for GPX4 enhances the anti-cancer activity of rapamycin in vitro or in vivo by promoting ferroptosis and suppressing autophagy 39. Here, GPX4 is linked to familial pancreatic carcinoma.