During the treatment of autoimmune diseases, particularly exemplified by RA, application of available anti-TNF biologics (monoclonal antibodies, e.g., certolizumab, adalimumab, golimumab and infliximab or soluble TNF receptors, e.g., etanercept) achieves seminal breakthrough since the new start of millennium 91. This evidence concerns the gene TNF and rheumatoid arthritis.