As shown in Table 3, LVI (P<0.001), T4 stage (P=0.031), stage IV (P=0.016), absence of adjuvant chemotherapy (P<0.001), and carcinoembryonic antigen (CEA) (P<0.001) were all independent risk factors for unfavorable OS in patients with CRC. The gene discussed is CEACAM5; the disease is colorectal carcinoma.