In conclusion, we identified 13 hub genes, VEGFA, TGFB1, TGFB2, TGFB3, IGF2, IGF1, EGF, FN1, KNG1, TIMP1, SERPINE1, THBS1 and VWF, that may be involved in the scleral ECM remodeling associated with glaucoma. Here, IGF1 is linked to glaucoma.