In conclusion, we identified 13 hub genes, VEGFA, TGFB1, TGFB2, TGFB3, IGF2, IGF1, EGF, FN1, KNG1, TIMP1, SERPINE1, THBS1 and VWF, that may be involved in the scleral ECM remodeling associated with glaucoma. This evidence concerns the gene TGFB1 and glaucoma.