The five most significantly enriched pathways were “AGE-RAGE signaling pathway in diabetic complications” (P=1.04E-22), “Proteoglycans in cancer” (P=3.04E-19), “Pathways in cancer” (P=1.88327E-16), “HIF-1 signaling pathway” (P=1.17E-12), and “Relaxin signaling pathway” (P= 1.34E-12), involving 23, 26, 34, 16, and 17 TMGs, respectively (Table 2). The gene discussed is HIF1A; the disease is cancer.