VPS35 and Parkinson disease: For instance, the mutational hot spot D620N substitution in vacuolarproteinsorting35 (VPS35) was reported to cause late‐onset autosomal dominant PD (Vilariño‐Güell et al., 2011; Zimprich et al., 2011) and has been identified in multiple familial PD cases, as well as sporadic patients, across different ethnic populations (Williams et al., 2017).