On the other hand, VPS35 D620N mutation can increase VPS35 interaction with mitochondrial DLP1 complexes and cause excessive mitochondrial fission and mitochondrial dysfunction through enhanced recycling of mitochondrial DLP1 complex in neuronal cells and fibroblasts from PD patients bearing VPS35 D620N mutation (Wang et al., 2016). Here, VPS35 is linked to Parkinson disease.