During our program of identifying molecule(s) that could play an inhibitory role against TNBC, we found that cellular communication network factor 5 (CCN5, previously known as WISP‐2), a matricellular 29–35 kDa protein and a member of the CCN family of growth factors, can modulate breast cancers by imparting an inhibitory effect on tumor progression.6, 7, 8, 9. This evidence concerns the gene CCN5 and breast cancer.