During our program of identifying molecule(s) that could play an inhibitory role against TNBC, we found that cellular communication network factor 5 (CCN5, previously known as WISP‐2), a matricellular 29–35 kDa protein and a member of the CCN family of growth factors, can modulate breast cancers by imparting an inhibitory effect on tumor progression.6, 7, 8, 9. Here, CCN5 is linked to breast carcinoma.