TGFB1 and Hepatic fibrosis: Capillarized LSEC in toxic liver fibrosis no longer prevent HSC activation [26], but exhibit a pro-fibrotic angiocrine program in LSEC with imbalance in activation from pro-regenerative CXCR7 to pro-fibrotic CXCR4 (FGFR1+, CXCR4+, TGF-β+, BMP2+, PDGFC+, CXCR7-, Id1-) that causes proliferation and expansion of Desmin-positive HSC [110].