Liver tumor-associated EC did not express LSEC, portal vein EC or central vein EC markers, but a signature related to portal vein EC (CD63, Ehd4, CD200) as well as Aplnr and Col18a1. Interestingly, EC adjacent to the tumor showed molecular characteristics with an intermediate state between normal LSEC and tumor endothelium [145]. The gene discussed is COL18A1; the disease is neoplasm.