GATA4 and Hepatic fibrosis: These findings are in line with recent findings showing that LSEC gene signatures including transcription factor Gata4 are significantly downregulated in a CDAA-diet-induced NASH model with perisinusoidal liver fibrosis, whereas continuous EC genes are induced including MYC target genes and the HSC-activating cytokine Pdgfb, which is not expressed by healthy, resting LSEC [61].