Recently, we have shown, for the first time, that MKRN3 knockout mice phenocopy many symptomatic features of human CPP (14), in contrast with the mice deficient of MKRN1 or MKRN2 that do not have phenotypes directly related to puberty, suggesting tissue-specific roles of the MAKORIN family proteins (15). This evidence concerns the gene MKRN3 and central precocious puberty.