Nevertheless, upon diabetes induction, where pancreatic β-cells are destroyed and no INS is produced, CLU OE seems to promote foxo1 activation, which along with its co-activator pgc-1 induce transcription of g6pc and pepck enzymes that participate in GLU production [25] in the liver; a fact that explains the increased GLU levels observed. This evidence concerns the gene FOXO1 and diabetes mellitus.