In the present study, in CRC cells in which SNHG4 was knocked down, we also observed S phase cell cycle arrest, as well as decreased CDK1, cyclin B1, and cyclin A2 protein levels, indicating that SNHG4 exerted its oncogenic effects on CRC cells by affecting the CDK1 levels and the cell cycle. Here, SNHG4 is linked to colorectal carcinoma.