CDK1 and colorectal carcinoma: Fang et al. [35] reported that overexpression of CCNB1 in two CRC cell lines, the HCT116 and SW480 cell lines, induced cancer cell hyperproliferation and local tumor growth; in contrast, CCNB1 knockdown in the same cell lines exerted opposite effects by regulating CDK1 to inhibit cell cycle progression.