Moreover, we observed significant negative correlations between ITIH1 expression and the mRNA expression of four DNA-methyltransferases (DNMT1, DNMT2, DNMT3A, and DNMT3B) in LIHC, while in other cancers, the correlations were mostly not significant or only significant for less than four DNMT members (Figure 7B). Here, DNMT1 is linked to cancer.