We found that ITIH1 was negatively correlated with TMB of CHOL, head and neck squamous cell carcinoma (HNSC), LUAD, PAAD, rectum adenocarcinoma (READ), STAD, and Thymoma (THYM), but positively correlated with that of Brain lower grade glioma (LGG) (Supplementary Figure 11A). Here, ITIH1 is linked to pancreatic adenocarcinoma.