By exploiting RNA-sequencing data of over 1,000 cell lines from the Cancer Cell Line Encyclopedia (CCLE) (https://www.broadinstitute.org/ccle), we were able to show that ITIH1-ITIH3 were most strongly expressed in liver cancer cell lines (ITIH4 expression seems to be silenced across all cancer cell lines) (Supplementary Figure 4). Here, ITIH1 is linked to liver cancer.