ITIH4 and cancer: Considering the genes queried, ITIH1 and ITIH4 were associated with either survival advantage or disadvantage in a number of cancer types, and ITIH2 and ITIH5 were only prognostically relevant in a few cancers, but increased expression of ITIH3 was predominantly associated with worse prognosis (for ACC, KIRC, KIRP, LUSC, and STAD) (Figure 4A).