Finally, we explored the transcriptional and translational levels of DNASE1L3 in the immortalized normal human hepatic cell line THLE-3 and multiple HCC cell lines, including the SMMC7721, SNU-387, HepG2, HepG2.2.15, HCCLM3 HCCLM9, and Huh7 cell lines. The gene discussed is DNASE1L3; the disease is hepatocellular carcinoma.