It has been linked to multiple oncogenic alterations such as mutations in tp53 and atrx (α-thalassemia/mental retardation X-linked syndrome) pten (phosphatase and tensin homologue) tert (telomerase reverse transcriptase) and h3f3a (histone H3.3) genes, codeletion of chromosome arms 1p and 19q, monosomy of chromosome 10, gains of chromosome 7, and egfr (epidermal growth factor receptor) and pdgfra (platelet-derived growth factor receptor-α) gene amplifications (118, 119, 120). Here, EGFR is linked to X-linked syndromic intellectual disability.