HA hydrogel stiffness also impacts adhesion and migration speed, implying that CD44 signaling is mechanosensitive (186) and pointing to additional biomolecules involved in mediating HA activity: CD44 suppression in U373MG and U87MG human GBM cells reduces cell adhesion to HA at short times (0.5 h) while maximal adhesion at 3 h requires both CD44 and integrins. Here, CD44 is linked to glioblastoma.