BCAN and central nervous system cancer: Jaworski et al. (131) reported that the extracellular hyaluronan-binding protein known as brevican or brain-enriched HA binding (BEHAN) is consistently expressed by human gliomas and enhanced HA-mediated glioma invasion, especially when cleaved by disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS4) (132, 133).