Beginning in 1994 with publication and PDB deposition of the earliest structure of human Src (Src homology domain 3 or SH3) by structural biologists at the Glaxo Research Institute (PDB ID: 1shd (83)), PDB structures have provided detailed insights into the biology of Src as a nonreceptor tyrosine kinase, its role as a driver of tumor growth, and inhibition by various small molecules. Here, SRC is linked to neoplasm.