THY1 and Parkinson disease: To assess whether the liver is susceptible to the accumulation of α-syn pathology in vivo, we turned to a widely used mouse model of PD overexpressing approximately 2 times the levels of human α-syn compared to mouse α-syn harboring the Ala30Pro mutation (A30P) under control of the neuronal Thy-1 promoter (Additional file 11: Table II) [52].