The high expression of TOX is under regulation of the transcription factors T cell acute lymphoblastic leukemia protein 1 (TAL1) and LIM domain only 1/2 (LMO1/2) and binds to the repair factors KU70/KU80 to inhibit their function, causing abnormal non-homologous end joining (NHEJ) repair, thus inhibiting DNA repair in T-ALL cells and reducing genome stability. The gene discussed is LMO1; the disease is acute lymphoblastic leukemia.