Our findings fit perfectly well with the fact that normal RUNX1 is a driver in RUNX1-related leukemogenesis including t(12;21) ETV6-RUNX1 BCP-ALL, t(8;21) AML1-ETO and inv [16] CBFβ-SMMHC acute myeloid leukemia [6, 49]. The gene discussed is MYH11; the disease is acute myeloid leukemia.