The fusion protein ETV6-RUNX1 sustains BCP-ALL, RUNX1-ETO is highly frequent in acute myeloid leukemia, RUNX1-MECOM leads to myelodysplasia and acute myeloid leukemia CBFA2T3-GLIS2, and RUNX1-CBFA2T3 is found in acute megakaryoblastic leukemia [6, 7, 17, 46]. Here, GLIS2 is linked to acute megakaryoblastic leukemia.