Nevertheless, this correlation between RUNX1 and CBFA2T3 expression is retrieved under enforced expression or depletion of RUNX1 or CBFA2T3 in two BCP-ALL cell lines, the REH cells (that express ETV6-RUNX1 transcript and protein) and Nalm6 cells (that do not express ETV6-RUNX1) (Fig. 1c). This evidence concerns the gene RUNX1 and acute lymphoblastic leukemia.