In order to investigate the consequence of CBFA2T3 protein in presence of RUNX1 transcription factor, similarly to what is observed in BCP-ALL patients’ cells (Fig. 1b) and in BCP-ALL cell lines (Fig. 1c), we also tested the impact of CBFA2T3 enforced expression with luciferase assays in HEK293 cells (Fig. 2c, d). The gene discussed is RUNX1; the disease is acute lymphoblastic leukemia.