With the homologous targeting and immune evasion abilities from the cancer cell membrane coating, and the oxygen delivery function of the PFTBA, the CCm–HSA–ICG–PFTBA improved the hypoxia in the tumor environment and enhanced the therapeutic efficacy of PDT in TNBC xenografts, indicating that CCm–HSA–ICG–PFTBA was able to contribute to the development of TNBC treatment. This evidence concerns the gene ALB and cancer.