ALB and neoplasm: On Day 7 and Day 14, the tumor-to-muscle radioactivity (T/M) ratio of the CCm–HSA–ICG–PFTBA with NIR group was significantly lower than that of the saline group (P = 0.03 and P = 0.04 on Day 7 and 14, respectively, Fig. 6a), and gradually decreased, while that of the other groups all increased (Fig. 6b).