The center targets, which may play a key role in GEB against CRC, namely, MAPK3, HSP90AA1, JUN, EGFR, CDK1, TNF, CCND1, ESR1, PRKACA, CCNA2, CDC25C, CDK2, CCNB1, AR, CREBBP, AURKA, CDC25A, CHEK1, BCL2L1, and PIK3CD. The gene discussed is ESR1; the disease is colorectal carcinoma.