PPI analysis of 136 targets revealed that the top 20 of center target genes, were MAPK3, HSP90AA1, JUN, EGFR, CDK1, TNF, CCND1, ESR1, PRKACA, CCNA2, CDC25C, CDK2, CCNB1, AR, CREBBP, AURKA, CDC25A, CHEK1, BCL2L1, and PIK3CD, which were likely to be crucial targets for GEB in treating CRC. This evidence concerns the gene CREBBP and colorectal carcinoma.