Meanwhile, 19α-hydroxygelsamydine fixed the binding cavity of CRC target EGFR through one H-bonds with residue including SER-720 (2.6 Å), and hydroxygelsamydine-MAPK3 was stabilized by two H-bonds with residues including TYR-53(3.1 Å) and GLU-50 (2.4 Å) (Fig. 8C, D). Here, EGFR is linked to colorectal carcinoma.