The center targets, which may play a key role in GEB against CRC, namely, MAPK3, HSP90AA1, JUN, EGFR, CDK1, TNF, CCND1, ESR1, PRKACA, CCNA2, CDC25C, CDK2, CCNB1, AR, CREBBP, AURKA, CDC25A, CHEK1, BCL2L1, and PIK3CD. The gene discussed is CDC25C; the disease is colorectal carcinoma.