Chang et al. [27] used 2DE-MALDI-TOF-MS technology to analyze BALF proteins of patients with ARDS on day 1, 3 and 7 after disease onset, and identified 37 proteins, most of which did not change significantly at three-time points, only a few proteins changed significantly, including annexin A3, surfactant protein A, actin, etc. The dynamic changes of BALF proteins not only reflect the repair of lung damage, but may also predict the prognosis of ARDS patients. The gene discussed is ANXA3; the disease is acute respiratory distress syndrome.