The binding of IL-35 and its receptors, IL-12Rβ2, gp130, or a heterodimer of IL-12Rβ2:gp130 activates the Janus kinase–signal transducer and activator of transcription (JAK-STAT) pathway and induces immunosuppression[14].In this regard, in a gene polymorphism analyses study among Japanese subjects, the authors reported that the frequencies of variant alleles of IL-12Rβ2 were significantly higher in aggressive periodontitis patients as compared with healthy controls or chronic periodontitis patients. Here, IL12RB2 is linked to chronic periodontitis.