The mean age at first RRS was 45 years for path_MLH1, 44 years for path_MSH2, 48 years for path_MSH6, and 53 years for path_PMS2 carriers, whereas the mean ages for first CRC were 41, 41, 44, and 47 years, respectively. The gene discussed is MSH2; the disease is colorectal carcinoma.