For younger carriers keen to mitigate their risks but also to avoid the surgical menopause, hysterectomy at the completion of childbearing followed by BSO at age 50 years would be an option for path_MLH1, path_MSH2, and particularly for path_MSH6 carriers, in whom the risk of premenopausal ovarian cancer is low. The gene discussed is MLH1; the disease is ovarian carcinoma.