In that study, treatment with BPs was not considered; instead, the very high prevalence of hypodontia and oligodontia prompted the group to investigate whether mutations in genes other than those earlier associated with OI (COL1A1, COL1A2, and CREB3L1) were responsible for the disturbances [27]. The gene discussed is COL1A2; the disease is osteogenesis imperfecta.