KEGG pathways showed that the pathways regarding the abovementioned DEGs were significantly associated with the biological behavior of OC, including PI3 K‐Akt signaling pathway, Pathways in cancer, p53 signaling pathway, Rap1 signaling pathway, Cell cycle, Alanine, aspartate and glutamate metabolism, Melanoma, and Biosynthesis of amino acids. This evidence concerns the gene TP53 and melanoma.