The KM plotter analysis shows that the expression of SFN (HR = 1.59 [1.4–1.81], low-rank P = 6.5e–13) (Fig. 4a) was engaged with worse OS for lung cancer patients, as well as DSP (HR = 1.47 [1.29–1.67], low-rank P = 3.9e–09) (Fig. 4b) and PHGDH (HR = 1.47 [1.29–1.66], low-rank P = 2.9e–09) (Fig. 4c) and identified 12 hub genes mean OS [HR = 1.45 [1.23–1.71], low-rank P = 1e–05] (Fig. 4d). This evidence concerns the gene DSP and lung cancer.