In this study, it was shown that AKT phosphorylation increased in the fibrotickidney by day 7 and that the expression of p-AKT continued to increase until day 14.This apparent and sustained increase in the level of p-AKT indicates that this proteinplays an important role in regulating the activation of renal interstitial fibroblastsand the progression of renal fibrosis after UUO. The gene discussed is AKT1; the disease is renal fibrosis.