Out of three matched partners (fibronectin, apolipoprotein E, and beta-amyloid peptide 1–42), fibronectin is highly relevant in the context of our study, since a high expression of this interstitial matrix molecule and integrin ligand in primary tumors resulted in decreased survival of breast cancer patients (Shinde et al. 2018). The gene discussed is APOE; the disease is breast carcinoma.