GPC3 and hepatocellular carcinoma: Indeed, individual glypicans have been identified as prognostic factors in oesophageal squamous cell carcinoma (GPC1) (Hara et al. 2016), hepatocellular carcinoma (GPC3) (Zhang et al. 2018a) and ovarian cancer (GPC6) (Karapetsas et al. 2015).