More precisely this has been shown for GPC1 in pancreatic cancer cells, where syndecan-1 and GPC1 are both required for FGF2-growth factor response leading to metastasis and shedding of GPC1 cannot be compensated for by higher levels of SDC1 (Ding et al. 2005). The gene discussed is GPC1; the disease is familial pancreatic carcinoma.