Of note, AR congenital hearing loss caused by, for example, GJB2 variants (DFN1B, OMIM 220290) is often categorized as moderately severe and not meeting several of the criteria discussed above.28 Still, in our center for PGT, it is one of the most frequently requested PGT indications (PGDnederland), adding patient experiences into the mix on the matter of disease severity opinion. Here, GJB2 is linked to hearing loss disorder.