Since dysfunction of these interneurons is implicated in the pathophysiology of neurological and neuropsychiatric diseases other than depression, including epilepsy [38], schizophrenia, autism [39], and memory dysfunction [40, 41], the SMARCA3/Neurensin-2 pathway is most likely implicated in these pathologies and in their future treatments. Here, NRSN2 is linked to major depressive disorder.