Interestingly, several TFEB downstream targets from the different categories (lysosomal hydrolases and accessory proteins, lysosomal membrane, lysosomal acidification, non-lysosomal proteins involved in lysosomal biogenesis and autophagy) are negatively associated with FASN transcript levels in two primary AML patient cohorts from TCGA analyzed using the UCSC Xena platform [60] and the Blood spot gene expression profiles data base [41] (Fig. 6A, Supplementary Fig. 5B-C Supplementary Table 1–2). The gene discussed is PROS1; the disease is acute myeloid leukemia.