SERPINA12 and obesity due to melanocortin 4 receptor deficiency: Vaspin was identified from visceral adipose tissues of OLETF (Otsuka Long-Evans Tokushima Fatty) rat, an animal model of obese and type 2 diabetes mellitus10, and we reported that vaspin inhibited obesity, insulin resistance, fatty liver11 and vascular endothelial cell apoptosis12.