In view of the adverse impact of high expression of TMCC3 on clinical outcome of breast cancer, which was corroborated by similar prognostic significance of TMCC3 in ovarian, lung and gastric cancers by data mining, and the negligible expression of TMCC3 mRNA in human vital organs (heart, lung, liver, and kidney) based on microarray database at the ONCOMINE, TMCC3 an ideal target for the design of therapeutics to eradicate CSCs in the future. This evidence concerns the gene TMCC3 and breast cancer.