ATR and colorectal cancer: In general, the cancers with higher ATM or ATR mutation frequencies tend to have higher number of mutated residues; for example, endometrial cancer, non-Hodgkin’s lymphoma, and colorectal cancer, with an ATM mutation frequency of 8–10% (Fig. 1e), each has over 100 mutated residues (Fig. 2a and Supplementary Table 1).