We performed a more detailed analysis on a few selected cancer types: for ATM, we chose colorectal cancer, endometrial cancer, and non-Hodgkin’s lymphoma because each has a comparable number of mutated residues that are conserved in Mec1 and/or Tel1, 54, 54, and 55, respectively (Fig. 2a). The gene discussed is ATR; the disease is endometrial cancer.