We also found that mice pre-treated with CAdTrio showed significantly higher HER2.CART infiltration/expansion (p < 0.005) at the tumor site within 7 days post infusion and increased circulating IFNγ (p = 0.004) in the blood compared to mice treated with HER2.CART alone at 7 days post infusion (Fig. 3b, c). Here, IFNG is linked to neoplasm.