To address which CAdTrio components (oncolysis, IL-12 and PD-L1 blocking antibody) contribute to sustained anti-tumor effects with HER2.CART in humanized mice, we administered CAd0 (no transgene), CAdPDL1 (PD-L1 blocking antibody), or CAdIL12 (IL-12p70) (Supplementary Fig. 15) to the right tumor of humanized mice bearing two subcutaneous CFPAC-1 tumors, as in the previous experiment. This evidence concerns the gene ERBB2 and neoplasm.