Mutations in many proteins in this interactome, such as LDB3, filamin C, myotilin, BAG3, DNAJB6, and HSPB8 lead to MFM phenotype5, indicating that most of the disease pathways converge onto a final pathway centered on the large LDB3-filamin C-CASA chaperone scaffold for this diverse group of myopathies. This evidence concerns the gene HSPB8 and myopathy.