CD4 and neoplasm: In the whole sample area, densities of all immune cell subtypes were significantly higher in HR− as compared with HR+ tumours [HR− median (interquartile range) CD3+ 1669(1818), CD8+ 689(955), CD4+ 629(884), Foxp3+ 187(215); HR+ median (interquartile range) CD3+ 828(863), CD8+ 383(520), CD4+ 361(472), Foxp3+ 57(89); P values, CD3+ = 0.009, CD8+ = 0.009, CD4+ = 0.019 and Foxp3+ < 0.001, Supplementary Fig. 13a].