In fact, densities of all immune cells subtypes increased at day 15 [median (interquartile range) CD3+ 1462(1453), CD8+ 688(526), CD4+ 534(684), Foxp3+ 166(219)] as compared to baseline [median (interquartile range) CD3+ 832(1795), CD8+ 364(841), CD4+ 445(684), Foxp3+ 83(141)] tumours (P values, significant only for CD8+ = 0.04, Supplementary Table 1, Supplementary Fig. 13c). This evidence concerns the gene CD4 and neoplasm.