CD3+ and CD8+ immune cell densities were inversely correlated with tumour area in on-treatment (day 15) samples (Spearman’s rho, CD3+ −0.367 P = 0.020, CD8+ −0.368; P = 0.010) but not in baseline samples (CD3+ −0.060; P = 0.620, CD8+ −0.014; P = 0.915; Supplementary Fig. 8b–c). Here, CD8A is linked to neoplasm.