Lower percentages of proliferating immune cells at day 15 were not significantly associated with lower tumour cellularity evaluated on the same sample (Spearman Rho, CD3+Ki67+ = 0.089, CD8+Ki67+ = 0.053, CD4+Ki67+ = 0.185, Foxp3+Ki67+ = 0.246, P > 0.05 for all comparisons) (Supplementary Fig. 11b, c). Here, CD4 is linked to neoplasm.