The proportion of proliferating immune cells was higher in HR- as compared with HR+ tumours (Wilcoxon, CD3+P = 0.007; CD8+P = 0.011; CD4+P = 0.009) except for Foxp3+ (P = 0.710) (Supplementary Fig. 13b, Supplementary Table 4). Here, CD4 is linked to neoplasm.