Using the pSer129-αSyn-specific 81A antibody (Fig. 1f–h) or anti-p62 antibody (Fig. 1i–k), we did not observe any significant induction of αSyn pathology in the Il-10-expressing mice compared to GFP-expressing controls, suggesting that Il-10-mediated immune dysregulation can cause neurotoxicity and accelerated death independent of obvious proteinopathy abnormalities. The gene discussed is IL10; the disease is proteostasis deficiencies.