To evaluate the pathological significance of the pro-metastatic activity of PRAK in human cancer, we first analyzed PRAK expression in a cohort of 60-non-small cell lung cancer (NSCLC) samples, which were subgrouped according to whether distant metastasis occurred within 5 years after surgical removal of the primary tumor. This evidence concerns the gene MAPKAPK5 and non-small cell lung carcinoma.