The mannose receptor is expressed in human spleens by Lyve-1+ cells lining venous sinuses, where they form a physical barrier for blood cells to exit the red pulp and so are ideally located to perform a filtering function.28 In infection with P. falciparum, the parasite evades passage through the spleen by expressing adhesive proteins, notably PfEMP1, on the surface of infected RBCs, so that they adhere to endothelial cells in the systemic circulation. Here, LYVE1 is linked to infection.