These data suggest that the CTCF mediated looping blocks rs11986220-containing rCRE and disrupts the co-regulation of MYC and PVT1. The co-regulation of these two genes is critical in cancer predisposition, as the oncogenic function of MYC is dependent on PVT1 expression and these two genes drive tumorigenesis synergistically78,79. The gene discussed is MYC; the disease is cancer.