TGFB1 and lung cancer: It is indispensable for TGF-β-induced EMT in lung cancer cells, and METTL3/m6A-mediated TGF-β signaling have been confirmed69,70, while the elevated TGF-β activity could lead to enhanced production of chemokine CCL22 by suppressing expression of microRNA-34a71, which recruits Treg cells to facilitate immune escape.