FTO and cancer: Yamamoto et al. demonstrate that suppression of autophagy favors MHC-I re-appearance on the surface of cancer cells because neighbor of BRCA1 gene 1 (NBR1) protein functions as an adaptor to target MHC-I proteins to autophagosomes and autolysosomes in PDAC cells, inducing efficient eradication by CTLs activation46, while the upregulated level of m6A modification could induce the activation of autophagy, and the FTO could decrease the m6A modification level of ULK1 to improve autophagy47.