Besides, inhibition of METTL3 and METTL14 could enhance the response to anti-PD1 treatment in melanoma, and tumor lack of METTL3 and METTL14 increases the cytotoxic tumor-infiltrating CD8 T cells and elevates secretion of IFN-γ, CXCL9, and CXCL10 in tumor58. The gene discussed is CD8A; the disease is neoplasm.