EPAS1 and neoplasm: It could result in enhanced translation of HIF-2α and promotes the aerobic glycolysis, which links one-carbon metabolism to HIF-2α-dependent metabolic reprogramming60, while hypoxia with hyperactivated HIF-1α and HIF-2α triggers CXCL12 expression in tumor cells61, fibroblasts62 and haematopoietic stem cells63.