Studies have shown that Caspase-1 can directly cleave IL-1β precursor (pro-IL-1β) and IL-18 precursor (pro-IL-18) to make them active IL-1β and IL-18, and release them to extracellular area becomes an inducer of inflammatory response and participates in the progression of inflammation-related tumors. The gene discussed is CASP1; the disease is inflammatory response.