We found that circSPI1s were mainly expressed in hematopoietic malignancies, e.g., acute myeloid leukemia (AML), chronic myeloid leukemia (CML), acute lymphocytic leukemia (ALL), chronic lymphocytic leukemia (CLL), myeloproliferative neoplasm (MPN), and multiple myeloma (MM), suggesting the hematopoietic lineage-specific pattern (Fig. 1B), similar to the lineage specificity observed for the parental SPI1 gene. The gene discussed is SPI1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.