In AML, circRNAs, derived from the pathogenesis-related genes, e.g., fusion drivers (PML/RARα and MLL/AF9)18, cell cycle genes (MYBL2)16, and epigenetics remodelers (ASXL1)19, have shown oncogenic effects in accelerating the development of leukemia. The gene discussed is PML; the disease is acute myeloid leukemia.