Using highly confident binding sites on these three miRNAs (Supplementary Table 4), we performed KEGG pathway enrichment analysis and found that these three miRNAs-mediated target genes were significantly involved in cancer pathways, including Ras, PI3K-Akt, p53, JAK-STAT, and FoxO signaling (Fig. 5F). The gene discussed is TP53; the disease is cancer.