Some studies have reported the association of hPER3 with obesity, for instance, PER3 methylation levels are related to childhood obesity42, hPER3 increased the BMI of those who sleep too late13, rs228669 of hPER3 showed association with triglycerides43, and cg10059324 also showed correlation with insulin resistance44. The gene discussed is PER3; the disease is obesity due to melanocortin 4 receptor deficiency.