Indeed, differential sensitivity of JIM-3 and H929 MM cells to anti-IGF-1 receptor antibodies has been reported—with enhanced sensitivity in JIM-3—demonstrating the distinct surface phenotypes of different MM cell lines.38 Furthermore, data presented in online supplemental figure S4A, and in our previously published work,6 showed that JIM-3 and U266B cells express higher levels of JAM-A and intercellular adhesion molecule-1 (important for cell adhesion) than other MM cell lines, therefore, enhanced cell-to-cell interactions may make these cells more amenable to HS-27 BMSC support. This evidence concerns the gene ICAM1 and Miyoshi myopathy.