APP and early-onset autosomal dominant Alzheimer disease: Seizures and epilepsy are a frequent co-morbidity in individuals with EOFAD which is caused by autosomal dominant mutations in APP, PSEN1, or PSEN2 genes, resulting in increased Aβ production and altered Aβ42/Aβ40 ratio (Noebels, 2011; Guerreiro and Hardy, 2014; Born, 2015).