Previously, disrupted hippocampal SWR associated spike dynamics (frequency and temporal structures) were reported in a tau-based transgenic mouse model of dementia, i.e., rTg4510 transgenic mice that express aggregating human tau P301L [a frontotemporal lobe dementia (FTD) mutation] and display NFTs but no Aβ pathology (Witton et al., 2016). This evidence concerns the gene MAPT and dementia.