MAPT and Cognitive impairment: However, the role of tau, the other major neuropathological hallmark of AD besides Aβ and a better correlate of cognitive impairment in AD (Nelson et al., 2012), in neuronal network excitability remains unclear with different studies reporting conflicting roles, i.e., enhancement versus suppression (Roberson et al., 2007; García-Cabrero et al., 2013; Holth et al., 2013; Angulo et al., 2017; Hatch et al., 2017; Mondragón-Rodríguez et al., 2018a; Busche et al., 2019).