While these findings are contradictory to other data showing neuronal network hyperactivity in both young and aged 3xTg-AD mice which harbor both Aβ and tau along with PS1 (Davis et al., 2014; Kazim et al., 2017), they are supported by another study in young 3xTg-AD mice which reported a decrease in neuronal activity in these mice (Mondragón-Rodríguez et al., 2018), this will be discussed in more detail later in the present review (see below, Phosphorylation of tau reduces hippocampal excitability). Here, PSEN1 is linked to Alzheimer disease.