However, the role of tau in network excitability in AD remains yet to be precisely delineated as different animal model studies reported divergent effects (Roberson et al., 2007; Crimins et al., 2011, 2012; Roberson et al., 2011; García-Cabrero et al., 2013; Menkes-Caspi et al., 2015; Angulo et al., 2017; Mondragón-Rodríguez et al., 2018b; Busche et al., 2019; Van Erum et al., 2020). The gene discussed is MAPT; the disease is Alzheimer disease.