While these findings are contradictory to other data showing neuronal network hyperactivity in both young and aged 3xTg-AD mice which harbor both Aβ and tau along with PS1 (Davis et al., 2014; Kazim et al., 2017), they are supported by another study in young 3xTg-AD mice which reported a decrease in neuronal activity in these mice (Mondragón-Rodríguez et al., 2018), this will be discussed in more detail later in the present review (see below, Phosphorylation of tau reduces hippocampal excitability). The gene discussed is MAPT; the disease is Alzheimer disease.