As neuronal network hyperexcitability is more clearly linked to Aβ (Palop and Mucke, 2010a,b, 2016; Zott et al., 2018), it is possible that epileptiform activity (as detected by EEG) is more prominent in AD patients who have comparatively higher Aβ than tau levels, or are at early stages of the disease when Aβ is present in the cortex but tau is limited to EC and limbic areas. Here, MAPT is linked to Alzheimer disease.