In AD and other related tauopathies, tau is abnormally hyperphosphorylated which results in reduced binding of tau to microtubules, and subsequent accumulation as NFTs, leading to neurodegeneration and cognitive impairment (Grundke-Iqbal et al., 1986a,b; Iqbal et al., 2016). The gene discussed is MAPT; the disease is Alzheimer disease.