MAPT and Alzheimer disease: Several studies have looked into the role of tau in neuronal network hyperexcitability in AD (Roberson et al., 2007; García-Cabrero et al., 2013; Holth et al., 2013; Angulo et al., 2017; Hatch et al., 2017; Mondragón-Rodríguez et al., 2018b; Busche et al., 2019); however, the data are conflicting with the precise role remaining yet to be elucidated.