While several studies over the past two decades have demonstrated that the interaction between Aβ and tau leads to increased pathology (Götz et al., 2001; Lewis et al., 2001; Hurtado et al., 2010; Wang et al., 2016; Bennett et al., 2017; Pontecorvo et al., 2017; Jacobs et al., 2018), the physiological consequences of this interaction on neuronal network excitability in AD is a matter of debate. Here, MAPT is linked to Alzheimer disease.