MAPT and Alzheimer disease: The main goals of this review are the following: (1) to provide an overview of the current knowledge on the association between abnormal network dysfunction and AD; (2) discuss the role of pathologic Aβ and tau on neuronal hyperexcitability; and (3) present potential hypotheses that can be tested for future studies, which could lead to more effective strategies to prevent, diagnose, and manage AD and related disorders.