MAPT and Seizure: Experimental paradigm: in vivo PTZ-induced and kainate-induced seizure susceptibility evaluation. tau reduction achieved through crossing hAPPJ20 line with tau knock-out (tau−/−).Findings: tau reduction increased resistance to both PTZ-and kainate-induced seizures. Seizures were less severe in hAPP/tau+/– and hAPP/tau–/– mice than in hAPP/tau+/+ mice. Seizures were also less severe in tau–/– mice than in tau+/+ mice. The onset of seizure was also delayed by tau reduction. tau reduction also ameliorated learning and memory deficits in hAPPJ20 mice.