While no amyloid plaques are present at this age in 3xTg-AD mice, they exhibit intraneuronal APP/Aβ expression; remarkably, epileptiform discharge duration positively correlated with intraneuronal transgenic hAPP/Aβ expression in the CA3 region of the hippocampus (Fig. 2G; Kazim et al., 2017). The gene discussed is APP; the disease is Alzheimer disease.