APP and early-onset autosomal dominant Alzheimer disease: Early-onset familial AD (EOFAD), caused by genetic mutations in APP, presenilin 1 (PSEN1), and presenilin 2 (PSEN2), is associated with a remarkable 87-fold higher seizure incidence compared with the general population (Amatniek et al., 2006; Cloyd et al., 2006).