MAPT and Mental deterioration: A previous study found that the A152T-variant of human tau (htau-A152T), known to increase the risk for both AD and non-AD tauopathies (Coppola et al., 2012), when expressed in transgenic mice neurons led to not only age-dependent cognitive decline, neurodegeneration, and gliosis, but also caused intermittent epileptic spike activity detectable by EEG (Maeda et al., 2016).