MAPT and semantic dementia: Previously, hyperexcitability and epileptic seizures were reported in FTDP-17 mouse model, a transgenic mouse line over-expressing a human tau isoform with 2 N-terminal inserts, 4-microtubule-binding-repeat elements and with the three FTDP-17-linked mutations G272V, P301L, and R406W (Fig. 3A–G; García-Cabrero et al., 2013).