rTg4510: 1–2 months, early stage tauopathy before overt tau hyperphosphorylation and synaptic impairment4–6 months, mid-stage with extensive tau hyperphosphorylation and impairment of synaptic activity and spatial memory12–14 months, late stage with synaptic loss and neurodegenerationPR5: 15–17 months, tau pathology in hippocampus. Here, MAPT is linked to tauopathy.