MAPT and Alzheimer disease: These differences could potentially be because of the inherent differences between preparations and recording techniques (Menkes-Caspi et al., 2015); however, further investigation is needed to clarify this discrepancy (we will discuss this in detail in Phosphorylation of tau reduces hippocampal excitability; and Perspectives on the Similar versus Divergent Roles of Aβ and tau in Neuronal Network Hyperexcitability in AD: Which One Has a Dominant Effect, Aβ or tau)?