CD8A and toxic epidermal necrolysis: It is probable that the main differences recorded between TEN and MPE (notably the differing CD4:CD8 ratio; Fig. 1) are due to the strong clonotype expansions and not the different type of tissues that we collected (TEN blisters versus MPE skin) because comparative analysis of adjacent blister skin in patients with TEN exhibited similar Vβ expansion and phenotype (figs.