TERT and cancer: TERT activity plays a central role in the unlimited self-renewal potential of cancer cells via telomerase activity that maintains telomere ends through addition of telomere repeats TTAGGG).17 This mechanism is considered one of the hallmarks of cancer.18 Various genomic alterations including TERT promoter mutations, rearrangements, amplifications, fusions, and promoter methylation have been well-characterized across human cancers.19–21 Limited information on the therapeutic implications of TERT genomic alterations are currently available.