Topo1 protein overexpression has been described in various cancers,15 whereas TOP1 gene amplification is a much rarer event in cancers (the highest amplification rate [>10%] was reported in gallbladder, esophageal, and gastroesophageal carcinomas).15 Our study revealed a common (50%–60%) Topo1 protein expression in both primary and metastatic LCT, whereas TOP1 gene amplification was observed in 1 metastatic case. Here, TOP1 is linked to cancer.